Postdoctoral fellow
My research interest lies in understanding how dysregulation of lysosomal signaling pathways and lysosome physiology contribute to neurological and neurodegenerative diseases. Using Drosophila Melanogaster as a model, I am investigating the roles of lysosomal genes in the pathogenesis and progression of Alzheimer's and Parkinson's diseases, and seeking to identify potential therapeutic targets.
Deger J, Hannan S, Gu M, Strohlein C, Goodman L, Pasupuleti S, Shaik Z, Ma L, Li Y, Li J, Stephens M, Liu Z, Al-Ramahi I, Botas J, Shaw C, Kanca O, Bellen HJ#, Shulman JM# (2025). Revealing the nervous system requirements of Alzheimer's disease risk genes in Drosophila American Journal of Human Genetics 112(12) 2870-2887 Abstract
Ravenscroft TA, Jacobs A, Gu M, Eberl DF, Bellen HJ (2023). The Voltage-gated sodium channel in Drosophila, Para, localizes to dendrites as well as axons in mechanosensitive chordotonal neurons eNeuro in press
Zhang X*, Gu M*, Hu M*, Yang Y, and Xu H. (2020). Endosomal and lysosomal electrophysiology Ion and Molecule Transport in Lysosomes 117(46) 29155-29165
Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, Sah R, Cover T, Chou J, Geha R, Benavides F, Hume R and Xu H. (2020). LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival in response to multiple physiological stresses Proceedings of the National Academy of Sciences 117(46) 29155-29165 Abstract
Li P*, Gu M*, Xu H. (2019). Lysosomal ion channels as decoders of cellular signals Trends in Biochemical Sciences 44(2) 110-124 Abstract
Yang J, Zhao Z, Gu M, Feng X, Xu H. (2019). Release and uptake mechanisms of vesicular Ca2+ stores Protein Cell 10(1) 8-19 Abstract
Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, Calvo R, Patnaik S, Wang W, King G, Samie M, Gao Q, Sahoo S, Sundaresan S, Keeley TM, Wang Y, Marugan J, Ferrer M, Samuelson LC, Merchant JL, Xu H. (2017). Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle Developmental Cell 41(3) 262-273 Abstract
Wang W, Zhang X, Gao Q, Lawas M, Yu L, Cheng X, Gu M, Sahoo N, Li X, Li P, Ireland S, Meredith A, Xu H. (2017). A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores Journal of Cell Biology 216(6) 1715-1730 Abstract
Gu M, Xu H. (2016). A painful TR(i)P to lysosomes Journal of Cell Biology 215(3) 309-312 Abstract
Sun X, Wu Y, Gu M, Liu Z, Ma Y, Li J, Zhang Y. (2014). Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models Proceedings of the National Academy of Sciences 111(39) 14271-6 Abstract
Sun X, Wu Y, Gu M, Zhang Y. (2014). MiR-342-5p Decreases Ankyrin G level in Alzheimer's disease transgenic mouse models Cell Reports 6(2) 264-270 Abstract