Our lab studies mechanisms that underlie neuronal development and function in the fruitfly, Drosophila melanogaster. We also develop new technologies to manipulate genes and create the reagents to implement these techniques for most fly genes. As the Drosophila Core of the Model Organisms Screening Center of the Undiagnosed Diseases Network we participate in the discovery of unknown human neurological diseases. Finally, we study the mechanisms of neurodegeneration associated with Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis and Friedreich Ataxia.
