Postdoctoral fellow
Millions of people worldwide are affected by rare genetic diseases, yet efficient diagnostic methods are lacking. By utilizing Drosophila and a range of genetic tools, I am able to model specific mutations in vivo and uncover the links between genetic mutations and the patient phenotypes. This modelling also facilitates the study of further pathological mechanisms and potential therapies. Notably, many rare diseases are associated with neurological symptoms, such as neurodevelopmental delays and epilepsy. Specifically, lipidomic disorders are suggested to play a significant role in neurological diseases, including Alzheimer and Parkinson disease. Therefore, I am also interested in exploring the systemic effects of lipidomic alterations in Drosophila neurological disease models.
Deng M, Wang Y, Yan Y. (2022). Mining cell-cell signaling in single-cell transcriptomics atlases Curr Opin Cell Biol 76 102101 Abstract
Deng M, Wang Y, Zhang L, Yang Y, Huang S, Wang J, Ge H, Ishibashi T, Yan Y. (2019). Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs Development 146(18) dev179754 Abstract
Ji T, Zhang L, Deng M, Huang S, Wang Y, Pham TT, Smith AA, Sridhar V, Cabernard C, Wang J, Yan Y. (2019). Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors Dis Model Mech. 12(8) dmm040147 Abstract
An Y, Xue G, Shaobo Y, Mingxi D, Zhou X, Yu W, Ishibashi T, Zhang L, Yan Y. (2017). Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts Development 144(12) 2153-2164 Abstract