Publications

Deger J, Hannan S, Gu M, Strohlein C, Goodman L, Pasupuleti S, Shaik Z, Ma L, Li Y, Li J, Stephens M, Liu Z, Al-Ramahi I, Botas J, Shaw C, Kanca O, Bellen HJ^#, Shulman JM^# (2025). Revealing the nervous system requirements of Alzheimer's disease risk genes in Drosophila American Journal of Human Genetics 112(12) 2870-2887 Abstract

Zhao X, Li Y, Zhang S, Sudwarts A, Zhang H, Kozlova A, Moulton MJ, Goodman LD, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, and Duan J. (2025). Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication Molecular Neurodegeneration 20(1) 51 Abstract

Park YJ*, Lu TC^*, Jackson T, Goodman LD, Ran L, Chen J, Liang CY, Harrison E, Ko C, Chen X, Wang B, Hsu AL, Ochoa E, Bieniek KF, Yamamoto S, Zhu Y, Zheng H, Qi Y, Bellen HJ^#, Li H^# (2025). Distinct systemic impacts of AB42 and Tau revealed by whole-organism snRNA-seq in Drosophila Neuron 113(13) S0896-6273(25)00299-5

Goodman LD, Ralhan I, Li X, Lu S, Moulton MJ, Park YJ, Zhao P, Kanca O, Ghaderpour Taleghani ZS, Jacquemyn J, Shulman JM, Ando K, Sun K, Ioannou MS, Bellen HJ (2024). Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress Nature Neuroscience 27(10) 1918-1933 Abstract

Goodman LD, Moulton MJ, Bellen HJ (2024). Glial lipid droplets resolve ROS during sleep Nat Neurosci 27(4) 610-612 Abstract

Ralhan I, Chang J, Moulton MJ , Goodman LD , Lee NYJ, Plummer G, Pasolli HA, Matthies D, Bellen HJ , Ioannou MS (2023). Autolysosomal exocytosis of lipids protect neurons from ferroptosis Journal of Cell Biology 222(6), doi: 10.1083/jcb.202207130 Abstract

Modrek, AS, Eskilsson, E, Ezhilarasan, R, Wang, Q, Goodman, LD, Ding, Y, Zhang, ZY, Bhat, KP, Le, TT, Barthel, FP, Tang, M, Yang, J, Long, L, Gumin, J, Lang, FF, Verhaak, RGW, Aldape, KD, Sulman, EP (2022). PDPN marks a subset of aggressive and radiation resistant glioblastoma cells Frontiers in Oncology 12 DOI:10.3389/fonc.2022.941657 Abstract

Moulton MJ, Barish S, Ralhan I, Chang J, Goodman LD, Harland JG, Marcogliese PC, Johansen J, Ioannou M, Bellen HJ (2021). Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer Disease-associated Genes PNAS 118(52) e2112095118 Abstract

Goodman LD, Bellen HJ (2021). Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila Current Opinion in Neurobiology DOI 10.1016/j.conb.2021.07.012 Abstract

Goodman LD, Cope H, Nil Z, Ravenscroft, TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Cogne B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O, UDN Consortia, Wangler MF, Yamamoto S, Bellen HJ*, Tan QKG* (2021). TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila American Journal of Human Genetics DOI 10.1016/j.ajhg.2021.06.019 Abstract

Goodman LD, Bonini, N.M. (2019). (review article) New roles for canonical factors in RNAPII-transcription of human repeat expansion diseases. Trends in Genetics 36(2) 81-92 Abstract

Goodman LD, Bonini, N.M (2019). (review article) Repeat-associated non-AUG (RAN) translation mechanisms running into focus for GGGGCC-repeat associated ALS/FTD Progress in Neurobiology 183 101697 Abstract

Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM (2019). Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD Nature Neuroscience 22 863-874 Abstract

Berson A*, Goodman LD*, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM (2019). Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies Acta Neuropathologica Communications 7 65 Abstract

Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM (2019). eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS Acta Neuropathologica Communications 7 62 Abstract

Yuan AL, Ricks CB, Bohm AK, Lun X, Maxwell L, Safdar S, Bukhari S, Gerber A, Sayeed W, Bering EA, Pedersen H, Chan JA, Shen Y, Marra M, Kaplan DR, Mason W, Goodman LD, Ezhilarasan R, Kaufmann AB, Cabral M, Robbins SM, Senger DL, Cahill DP, Sulman EP, Cairncross JG, Blough MD (2018). ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts PLoS One 13 e0202860 Abstract

Mordes DA, Prudencio M*, Goodman LD*, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K (2018). Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients Acta Neuropathologica Communications 6 55 Abstract

Olar A, Goodman LD, Wani KM, Boehling NS, Sharma DS, Mody RR, Gumin J, Claus EB, Lang FF, Cloughesy TF, Lai A, Aldape KD, DeMonte F, Sulman EP (2018). A gene expression signature predicts recurrence-free survival in meningioma Oncotarget 9 16087-16098 Abstract

Shahar T, Rozovski U, Hess KR, Hossain A, Gumin J, Gao F, Fuller GN, Goodman LD, Sulman EP, Lang FF (2017). Percentage of mesenchymal stem cells in high-grade glioma tumor samples correlates with patient survival Neuro-Oncology 19 660-668 Abstract

Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW 3rd, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD (2016). Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts Science 353 708-712 Abstract

Yu Z, Goodman LD, Shieh SY, Min M, Teng X, Zhu Y, Bonini NM (2015). A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1 Human Molecular Genetics 24 954-962 Abstract

Bhat KPL, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WFA, Boddeke HWGM, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K (2013). Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma Cancer Cell 24 331-346 Abstract